Extracellular Vesicles and Cancer Multidrug Resistance: Undesirable Intercellular Messengers?

Cancer multidrug resistance (MDR) is one of the main mechanisms contributing to therapy failure and mortality. Overexpression drug transporters ABC family (ATP-binding cassette) a major cause MDR. Extracellular vesicles (EVs) are nanoparticles released by most cells organism involved in cell–cell communication. Their cargo mainly comprises, proteins, nucleic acids, lipids, which transferred from donor cell target lead phenotypical changes. In this article, we review scientific evidence addressing regulation EV-mediated MDR transfer drug-resistant drug-sensitive has been identified several tumor entities. This was attributed, some cases, direct shuttle transporter molecules or its coding mRNA between cells. Also, transport regulatory proteins (e.g., transcription factors) noncoding RNAs have indicated induce Conversely, phenotype via EVs also reported. Additionally, interactions non-tumor with an impact on presented. Finally, highlight uninvestigated aspects possible approaches exploiting knowledge toward identification druggable processes and, ultimately, development novel therapeutic strategies.